ANTIPSYCHOTIC AND NEUROPROTECTIVE ACTIONS OFBERGENIA CILIATA ROOT EXTRACT IN RAT MODELS

Abstract

Traditional remedies, along with the phytochemicals and antioxidants included in plants, may assist individuals suffering from psychosis, a persistent mental condition. These compounds and antioxidants safeguard organ health while also reducing the chance of schizophrenia. The efficacy of Bergenia ciliata as an antidepressant was evaluated using a methanolic root extract. Subsequently, it was examined in rat models exhibiting psychotic symptoms. Biochemical assays were conducted on cerebral tissue to detect TNF-α, glutathione (GSH), and acetylcholinesterase (AchE) to ascertain inflammation. Alongside histological examinations of the frontal cortex and hippocampus, behavioral assessments were conducted to evaluate the animals' locomotion and conduct. The apomorphine control group demonstrated more stereotypy than the B. ciliata 60 and 90 minute dosing groups and the apomorphine plus conventional therapy group. Moreover, substantial disparities were observed in the levels of GSH, AchE, and TNF-α across the three groups: the control group, the group administered B. ciliata, and the group receiving haloperidol as a traditional treatment. The actophotometer data indicated no more significant alterations, save for a reduction in the positive control group. Following the administration of diazepam, the B. ciliata group exhibited enhanced motility. Histological investigations indicated that the neuronal structures in the treated groups were unaltered, and the overall architecture of the hippocampus and cortex was maintained in B. ciliata. The brains administered diazepam exhibited the minimal extent of damage. The findings indicate that B. ciliata may possess neuroprotective and antipsychotic properties by reducing inflammation and enhancing brain structure and function.